Gene_name | Experimentally Verified Resistance Gene Information | Predicted Resistance Gene Information |
cmeA | BacMet ID: BAC0068Code for:
EffluxFamily: RND superfamily, MFP familySequence: FASTACross-database IDs: LinkOrganism: Campylobacter jejuniLocation:
ChromosomeCompound: Copper (Cu), Cobalt (Co), Sodium Chenodeoxycholate [class: Acid], Sodium Deoxycholate [class: Acid], Sodium Cholate [class: Acid], Sodium Taurocholate [class: Acid], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Ethidium Bromide [class: Phenanthridine]Description: RND efflux system, a periplasmic fusion protein CmeA. Part of the CmeABC multidrug efflux system in Campylobacter jejuni.Length (amino acid):
367Reference: Lin et al. 2002; Pubmed- 12069964
| Similar
resistance genes in 'BacMet Predicted database' |
cmeB | BacMet ID: BAC0613Code for:
EffluxFamily: RND superfamilySequence: FASTACross-database IDs: LinkOrganism: Campylobacter jejuniLocation:
ChromosomeCompound: Copper (Cu), Cobalt (Co), Sodium Chenodeoxycholate [class: Acid], Sodium Deoxycholate [class: Acid], Sodium Cholate [class: Acid], Sodium Taurocholate [class: Acid], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Ethidium Bromide [class: Phenanthridine], Acridine orange [class: Acridine]Description: An inner membrane efflux transporter. Part of the CmeABC multidrug efflux system in Campylobacter jejuni.Length (amino acid):
1040Reference: Lin et al. 2002; Pubmed- 12069965, Pumbwe et al. 2004; Pubmed- 15201231
| Similar
resistance genes in 'BacMet Predicted database' |
cmeC | BacMet ID: BAC0614Code for:
EffluxFamily: RND superfamily, OMF familySequence: FASTACross-database IDs: LinkOrganism: Campylobacter jejuniLocation:
ChromosomeCompound: Copper (Cu), Cobalt (Co), Sodium Chenodeoxycholate [class: Acid], Sodium Deoxycholate [class: Acid], Sodium Cholate [class: Acid], Sodium Taurocholate [class: Acid], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Ethidium Bromide [class: Phenanthridine] Description: An outer membrane protein (CmeC). Part of the CmeABC multidrug efflux system in Campylobacter jejuni.Length (amino acid):
492Reference: Lin et al. 2002; Pubmed- 12069966
| Similar
resistance genes in 'BacMet Predicted database' |
cmtR | BacMet ID: BAC0071Code for:
RegulatorFamily: Contains 1 HTH arsR-type DNA-binding domain.Sequence: FASTACross-database IDs: LinkOrganism: Mycobacterium tuberculosisLocation:
ChromosomeCompound: Cobalt (Co), Nickel (Ni)Description: Metal-responsive transcriptional repressor for the cmt operon. Binding of cadmium or lead causes the repressor to dissociate from the DNA.Length (amino acid):
118Reference: Cavet et al. 2003; Pubmed- 12939264
| Similar
resistance genes in 'BacMet Predicted database' |
cnrA | BacMet ID: BAC0203Code for:
EffluxFamily: RND superfamily, AcrB/AcrD/AcrF familySequence: FASTACross-database IDs: LinkOrganism: Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839)Location:
Plasmid pMOL28 (Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839))Compound: Cobalt (Co), Nickel (Ni)Description: Nickel and cobalt resistance protein CnrA. The products of the genes cnrA, cnrB, and cnrC are likely to form a membrane-bound protein complex catalyzing an energy-dependent efflux of Ni2+ and Co2+. The mechanism of action of the CnrCBA complex may be that of a proton/cation antiporter.Length (amino acid):
1076Reference: Liesegang et al. 1993; Pubmed- 8380802, Grass et al. 2000; Pubmed- 10671463
| Similar
resistance genes in 'BacMet Predicted database' |
cnrA | BacMet ID: BAC0542Code for:
EffluxFamily: RND superfamilySequence: FASTACross-database IDs: LinkOrganism: Bradyrhizobium sp. STM 2465Location:
ChromosomeCompound: Cobalt (Co), Nickel (Ni)Description: Fragment of nccA-like proteinLength (amino acid):
304Reference: Chaintreuil et al. 2007; Pubmed- 17951443
| Similar
resistance genes in 'BacMet Predicted database' |
cnrA | BacMet ID: BAC0543Code for:
EffluxFamily: RND superfamilySequence: FASTACross-database IDs: LinkOrganism: Bradyrhizobium sp. STM 2464Location:
ChromosomeCompound: Cobalt (Co), Nickel (Ni)Description: Fragment of nccA-like proteinLength (amino acid):
304Reference: Chaintreuil et al. 2007; Pubmed- 17951443
| Similar
resistance genes in 'BacMet Predicted database' |
cnrA | BacMet ID: BAC0544Code for:
EffluxFamily: RND superfamilySequence: FASTACross-database IDs: LinkOrganism: Bradyrhizobium sp. STM 2457Location:
ChromosomeCompound: Cobalt (Co), Nickel (Ni)Description: Fragment of nccA-like proteinLength (amino acid):
304Reference: Chaintreuil et al. 2007; Pubmed- 17951443
| Similar
resistance genes in 'BacMet Predicted database' |
cnrA | BacMet ID: BAC0545Code for:
EffluxFamily: RND superfamilySequence: FASTACross-database IDs: LinkOrganism: Bradyrhizobium sp. STM 2460Location:
ChromosomeCompound: Cobalt (Co), Nickel (Ni)Description: Fragment of nccA-like proteinLength (amino acid):
304Reference: Chaintreuil et al. 2007; Pubmed- 17951443
| Similar
resistance genes in 'BacMet Predicted database' |
cnrA | BacMet ID: BAC0546Code for:
EffluxFamily: RND superfamilySequence: FASTACross-database IDs: LinkOrganism: Bradyrhizobium sp. STM 2458Location:
ChromosomeCompound: Cobalt (Co), Nickel (Ni)Description: Fragment of nccA-like proteinLength (amino acid):
304Reference: Chaintreuil et al. 2007; Pubmed- 17951443
| Similar
resistance genes in 'BacMet Predicted database' |
cnrB | BacMet ID: BAC0204Code for:
EffluxFamily: Membrane Fusion Protein (MFP) familySequence: FASTACross-database IDs: LinkOrganism: Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839)Location:
Plasmid pMOL28 (Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839))Compound: Cobalt (Co), Nickel (Ni)Description: Nickel and cobalt resistance protein CnrB. The products of the genes cnrA, cnrB, and cnrC are likely to form a membrane-bound protein complex catalyzing an energy-dependent efflux of Ni2+ and Co2+. The mechanism of action of the CnrCBA complex may be that of a proton/cation antiporter.Length (amino acid):
395Reference: Liesegang et al. 1993; Pubmed- 8380802, Grass et al. 2000; Pubmed- 10671463
| Similar
resistance genes in 'BacMet Predicted database' |
cnrC | BacMet ID: BAC0072Code for:
EffluxFamily: RND Superfamily, OMP familySequence: FASTACross-database IDs: LinkOrganism: Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839)Location:
Plasmid pMOL28 (Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839))Compound: Cobalt (Co), Nickel (Ni)Description: Nickel and cobalt resistance protein CnrC; The products of the genes cnrA, cnrB, and cnrC are likely to form a membrane-bound protein complex catalyzing an energy-dependent efflux of Ni2+ and Co2+. The mechanism of action of the CnrCBA complex may be that of a proton/cation antiporter.Length (amino acid):
418Reference: Liesegang et al. 1993; Pubmed- 8380802, Grass et al. 2000; Pubmed- 10671463
| Similar
resistance genes in 'BacMet Predicted database' |
cnrH | BacMet ID: BAC0073Code for:
RegulatorFamily: Sigma-70 factor familySequence: FASTACross-database IDs: LinkOrganism: Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839)Location:
Plasmid pMOL28 (Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839))Compound: Cobalt (Co), Nickel (Ni)Description: RNA polymerase sigma factor CnrH; CnrH alone is able to activate cnr Expression, and both CnrY and CrnX are needed for nickel induction of CnrH. In the absence of wild-type CnrY (due either to a frameshift or absence of the transcript, nickel and cobalt resistance is constitutive, indicating that CrnY may act as a repressor or an anti-sigma factor.Length (amino acid):
191Reference: Liesegang et al. 1993; Pubmed- 8380802, Grass et al. 2000; Pubmed- 10671463
| Similar
resistance genes in 'BacMet Predicted database' |
cnrR/cnrX | BacMet ID: BAC0291Code for:
RegulatorFamily: UnknownSequence: FASTACross-database IDs: LinkOrganism: Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839)Location:
Plasmid pMOL28 (Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839))Compound: Cobalt (Co), Nickel (Ni)Description: Nickel and cobalt resistance operon regulator CnrR. CnrH alone is able to activate cnr expression, while both CnrY and CnrR (CnrX) are needed for nickel induction of CnrH. Has been suggested to bind nickel.Length (amino acid):
148Reference: Liesegang et al. 1993; Pubmed- 8380802, Grass et al. 2000; Pubmed- 10671463, Tibazarwa et al. 2000; Pubmed- 10671464
| Similar
resistance genes in 'BacMet Predicted database' |
cnrT | BacMet ID: BAC0074Code for:
Membrane TransporterFamily: EamA-like transporter familySequence: FASTACross-database IDs: LinkOrganism: Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839)Location:
Plasmid pMOL28 (Cupriavidus metallidurans)Compound: Cobalt (Co), Nickel (Ni)Description: CnrT, Cation Diffusion Facilitator, involved in Co(II), Ni(II) resistanceLength (amino acid):
351Reference: Grass et al. 2000; Pubmed- 10671463
| Similar
resistance genes in 'BacMet Predicted database' |
cnrY | BacMet ID: BAC0075Code for:
RegulatorFamily: UnknownSequence: FASTACross-database IDs: LinkOrganism: Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839)Location:
Plasmid pMOL28 (Cupriavidus metallidurans)Compound: Cobalt (Co), Nickel (Ni)Description: Nickel and cobalt resistance protein CnrY; CnrY and CnrX are needed for nickel induction of CnrH. In the absence of wild-type CnrY (due either to a frameshift) or absence of the transcript, nickel and cobalt resistance is constitutive, indicating that CrnY may act as a repressor or an anti-sigma factor.Length (amino acid):
95Reference: Liesegang et al. 1993; Pubmed- 8380802, Grass et al. 2000; Pubmed- 10671463
| Similar
resistance genes in 'BacMet Predicted database' |
corA | BacMet ID: BAC0086Code for:
Membrane TransporterFamily: CorA metal ion transporter (MIT) familySequence: FASTACross-database IDs: LinkOrganism: Escherichia coli (strain K12)Location:
ChromosomeCompound: Magnesium (Mg), Cobalt (Co), Nickel (Ni), Manganese (Mn)Description: Mediates influx of magnesium ions. Can also mediate cobalt and manganese uptake, albeit only at extracellular concentrations that are toxic to the cell. Does not transport iron.Length (amino acid):
316Reference: Park et al. 1976; Pubmed- 780341
| Similar
resistance genes in 'BacMet Predicted database' |
corA | BacMet ID: BAC0641Code for:
Membrane TransporterFamily: CorA metal ion transporter (MIT) familySequence: FASTACross-database IDs: LinkOrganism: Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)Location:
ChromosomeCompound: Magnesium (Mg), Cobalt (Co), Nickel (Ni), Manganese (Mn)Description: Mediates both influx and efflux of magnesium ions. Can also mediate cobalt and nickel uptake, albeit only at extracellular concentrations that are toxic to the cell. Does not transport iron.Length (amino acid):
316Reference: Smith et al. 1998; Pubmed- 9786860, Gibson et al. 1991; Pubmed- 1779764, Hmiel et al. 1989; Pubmed- 2548998
| Similar
resistance genes in 'BacMet Predicted database' |
corB | BacMet ID: BAC0643Code for:
EnzymeFamily: Cation transport ATPase (P-type) familySequence: FASTACross-database IDs: LinkOrganism: Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)Location:
ChromosomeCompound: Cobalt (Co), Magnesium (Mg)Description: Magnesium-transporting ATPase, P-type 1; Mediates magnesium influx to the cytosol.Length (amino acid):
227Reference: Gibson et al. 1991; Pubmed- 1779764, Hmiel et al. 1989; Pubmed- 2548998
| Similar
resistance genes in 'BacMet Predicted database' |
corC | BacMet ID: BAC0088Code for:
EffluxFamily: UPF0053 family. Contains 2 CBS domains.Sequence: FASTACross-database IDs: LinkOrganism: Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)Location:
ChromosomeCompound: Cobalt (Co), Magnesium (Mg)Description: Magnesium and cobalt efflux protein CorC; Plays a role in the transport of magnesium and cobalt ionsLength (amino acid):
292Reference: Gibson et al. 1991; Pubmed- 1779764, Hmiel et al. 1989; Pubmed- 2548998
| Similar
resistance genes in 'BacMet Predicted database' |
corD | BacMet ID: BAC0644Code for:
UnknownFamily: Contains 1 apaG domainSequence: FASTACross-database IDs: LinkOrganism: Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)Location:
ChromosomeCompound: Cobalt (Co), Magnesium (Mg)Description: mutations in apaG/corD give a phenotype of low-level Co2+ resistance. They also decrease Mg2+ efflux but not influx via the CorA Mg2+ transport system.Length (amino acid):
125Reference: Gibson et al. 1991; Pubmed- 1779764, Hmiel et al. 1989; Pubmed- 2548998
| Similar
resistance genes in 'BacMet Predicted database' |
corR/coaR | BacMet ID: BAC0090Code for:
RegulatorFamily: MerR familySequence: FASTACross-database IDs: LinkOrganism: Synechocystis sp. PCC 6803 substr. GT-ILocation:
ChromosomeCompound: Cobalt (Co), Magnesium (Mg)Description: Cobalt-dependent transcriptional regulator, CorRLength (amino acid):
370Reference: Rutherford et al. 1999; Pubmed- 10464323, Garcia-Dominquez et al. 2000; Pubmed- 10692354
| Similar
resistance genes in 'BacMet Predicted database' |
corT/coaT | BacMet ID: BAC0092Code for:
EnzymeFamily: Cation transport ATPase (P-type) familySequence: FASTACross-database IDs: LinkOrganism: Synechocystis sp. PCC 6803 substr. GT-ILocation:
ChromosomeCompound: Cobalt (Co)Description: Cation-transporting ATPase E1-E2 ATPase, CorTLength (amino acid):
642Reference: Rutherford et al. 1999; Pubmed- 10464323, Garcia-Dominquez et al. 2000; Pubmed- 10692354
| Similar
resistance genes in 'BacMet Predicted database' |
ctpD | BacMet ID: BAC0099Code for:
EnzymeFamily: Cation transport ATPase (P-type)family. Type IB subfamilySequence: FASTACross-database IDs: LinkOrganism: Mycobacterium smegmatisLocation:
ChromosomeCompound: Cobalt (Co), Nickel (Ni)Description: Probable cobalt/nickel-exporting P-type ATPase; Involved in heavy metal homeostasis. Probably exports nickel and cobalt ions out of the cell.Length (amino acid):
657Reference: Raimunda et al. 2012; Pubmed- 22591178
| Similar
resistance genes in 'BacMet Predicted database' |
czcA | BacMet ID: BAC0119Code for:
EffluxFamily: RND superfamily, AcrB/AcrD/AcrF familySequence: FASTACross-database IDs: LinkOrganism: Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839)Location:
Plasmid pMOL30 (Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839) ),Compound: Cadmium (Cd), Zinc (Zn), Cobalt (Co)Description: Cobalt-zinc-cadmium resistance protein; the basic inner membrane transport protein; Has a low cation transport activity for cobalt, it is essential for the expression of cobalt, zinc, and cadmium resistance. CzcA and CzcB together would act in zinc efflux nearly as effectively as the complete CZC efflux system (CzcABC).Length (amino acid):
1063Reference: Nies et al. 1989; Pubmed- 2678100
| Similar
resistance genes in 'BacMet Predicted database' |
czcB | BacMet ID: BAC0120Code for:
EffluxFamily: Membrane fusion protein (MFP) familySequence: FASTACross-database IDs: LinkOrganism: Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839)Location:
Plasmid pMOL30 (Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839) ),Compound: Cadmium (Cd), Zinc (Zn), Cobalt (Co)Description: Cobalt-zinc-cadmium resistance protein CzcB; Membrane fusion protein bridges inner and outer cell membranes (in periplasm); CzcA and CzcB together would act in zinc efflux nearly as effectively as the complete czc efflux system (CzcABC). The CzcB protein is thought to funnel zinc cations to the CzcA transport protein.Length (amino acid):
520Reference: Nies et al. 1989; Pubmed- 2678100, Waidner et al. 2002; Pubmed- 12426358
| Similar
resistance genes in 'BacMet Predicted database' |
czcC | BacMet ID: BAC0121Code for:
EffluxFamily: RND Superfamily, OMP familySequence: FASTACross-database IDs: LinkOrganism: Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839)Location:
Plasmid pMOL30 (Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839) ),Compound: Cadmium (Cd), Zinc (Zn), Cobalt (Co)Description: Muter membrane protein; CzcC protein appears to modify the specificity of the system, perhaps by acting on the CzcB protein. When the CzcC protein is added to CzcA and CzcB, the efflux system gains specificity for cadmium and cobalt.Length (amino acid):
418Reference: Nies et al. 1989; Pubmed- 2678100
| Similar
resistance genes in 'BacMet Predicted database' |
czcD | BacMet ID: BAC0122Code for:
EffluxFamily: Cation diffusion facilitator (CDF) transporter familySequence: FASTACross-database IDs: LinkOrganism: Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839)Location:
Plasmid pMOL30 (Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839) ),Compound: Cadmium (Cd), Zinc (Zn), Cobalt (Co)Description: Transporter gene influence Zn++ and Cd++ resistance; Necessary for activation of the czc determinant; may function as a membrane-bound sensor protein or as a metal ion transporter.Length (amino acid):
316Reference: Nies et al. 1989; Pubmed- 2678100
| Similar
resistance genes in 'BacMet Predicted database' |
czcE | BacMet ID: BAC0123Code for:
Binding proteinFamily: Cation efflux familySequence: FASTACross-database IDs: LinkOrganism: Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839)Location:
Plasmid pMOL30 (Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839) ),Compound: Cadmium (Cd), Zinc (Zn), Cobalt (Co)Description: CzcE, involved in Cd(II), Zn(II), Co(II) resistance; copH like protein; Co/Zn/Cd efflux system transmembrane proteinLength (amino acid):
133Reference: Zoropogui et al. 2007; Pubmed- 18029263
| Similar
resistance genes in 'BacMet Predicted database' |
czcP | BacMet ID: BAC0124Code for:
EnzymeFamily: Cation transport ATPase (P-type) familySequence: FASTACross-database IDs: LinkOrganism: Cupriavidus metallidurans CH34Location:
Plasmid pMOL30 (Cupriavidus metallidurans CH34)Compound: Cadmium (Cd), Zinc (Zn), Cobalt (Co)Description: P(IB4)-type ATPases; CzcP seemed to enhance metal resistance but relies on the action of the P(IB2)-type ATPases such as zntA, cadA, pbrA etc.Length (amino acid):
829Reference: Scherer et al. 2009; Pubmed- 19602147
| Similar
resistance genes in 'BacMet Predicted database' |
czcR | BacMet ID: BAC0125Code for:
RegulatorFamily: Contains 1 response regulatory domainSequence: FASTACross-database IDs: LinkOrganism: Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839)Location:
Plasmid pMOL30 (Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839) ),Compound: Cadmium (Cd), Zinc (Zn), Cobalt (Co)Description: Transcriptional activator protein CzcR; Member of the two-component regulatory system CzcS/CzcR involved in the control of cobalt, zinc and cadmium homeostasisLength (amino acid):
225Reference: Nies et al. 1992; Pubmed- 1459958
| Similar
resistance genes in 'BacMet Predicted database' |
czcS | BacMet ID: BAC0126Code for:
RegulatorFamily: Contains 1 HAMP domain, 1 histidine kinase domainSequence: FASTACross-database IDs: LinkOrganism: Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839)Location:
Plasmid pMOL30 (Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839) )Compound: Cadmium (Cd), Zinc (Zn), Cobalt (Co)Description: Sensor protein CzcS; Member of the two-component regulatory system CzcS/CzcR involved in the control of cobalt, zinc and cadmium homeostasis. Probably activates CzcR by phosphorylation.Length (amino acid):
476Reference: Van der Lelie et al. 1997; Pubmed- 9044283
| Similar
resistance genes in 'BacMet Predicted database' |
dmeF | BacMet ID: BAC0132Code for:
EffluxFamily: Cation diffusion facilitator (CDF) transporter familySequence: FASTACross-database IDs: LinkOrganism: Wautersia metallidurans CH34Location:
Plasmid pMOL28 (Wautersia metallidurans CH34)Compound: Cobalt (Co), Cadmium (Cd), Nickel (Ni)Description: DmeF is a broad-range metal ion transporter that functions in E. coli and W. metallidurans. dmeF plays the central role in cobalt homeostasis in Wautersia metallidurans CH34.Length (amino acid):
382Reference: Scherer et al. 2009; Pubmed- 19602147, Munkelt et al. 2004; Pubmed- 15547276
| Similar
resistance genes in 'BacMet Predicted database' |
dmeF | BacMet ID: BAC0482Code for:
EffluxFamily: Cation Diffusion Facilitator (CDF) familySequence: FASTACross-database IDs: LinkOrganism: Rhizobium leguminosarum bv. viciae UPM791Location:
ChromosomeCompound: Cobalt (Co), Nickel (Ni)Description: Member of the dmeRF efflux system which is a metal responsive efflux system acts as a key element for metal homeostasis in Rhizobium leguminosarum under free-living and symbiotic conditions. Length (amino acid):
323Reference: Rubio-Sanz et al. 2013; Pubmed- 23934501
| Similar
resistance genes in 'BacMet Predicted database' |
dmeR | BacMet ID: BAC0475Code for:
EffluxFamily: Cation Diffusion Facilitator (CDF) familySequence: FASTACross-database IDs: LinkOrganism: Rhizobium leguminosarum bv. viciae UPM791Location:
ChromosomeCompound: Cobalt (Co), Nickel (Ni)Description: Member of the dmeRF efflux system which is a metal responsive efflux system acts as a key element for metal homeostasis in Rhizobium leguminosarum under free-living and symbiotic conditions. Length (amino acid):
90Reference: Rubio-Sanz et al. 2013; Pubmed- 23934501
| Similar
resistance genes in 'BacMet Predicted database' |
fecD | BacMet ID: BAC0163Code for:
EnzymeFamily: Binding-protein-dependent transport system permease family. FecCD subfamilySequence: FASTACross-database IDs: LinkOrganism: Escherichia coli (strain K12)Location:
ChromosomeCompound: Nickel (Ni), Cobalt (Co)Description: Fe(3+) dicitrate transport system permease protein FecD; Part of the binding-protein-dependent transport system for citrate-dependent Fe3+. Probably responsible for the translocation of the substrate across the membrane.Length (amino acid):
318Reference: Stoof et al. 2010; Pubmed- 20643857
| Similar
resistance genes in 'BacMet Predicted database' |
fecE | BacMet ID: BAC0164Code for:
Membrane TransporterFamily: ABC transporter superfamilySequence: FASTACross-database IDs: LinkOrganism: Escherichia coli (strain K12)Location:
ChromosomeCompound: Nickel (Ni), Cobalt (Co)Description: Fe(3+) dicitrate transport ATP-binding protein FecE; Part of the binding-protein-dependent transport system for citrate-dependent Fe3+. Probably responsible for energy coupling to the transport systemLength (amino acid):
255Reference: Stoof et al. 2010; Pubmed- 20643857
| Similar
resistance genes in 'BacMet Predicted database' |
fieF/yiip | BacMet ID: BAC0167Code for:
EffluxFamily: Cation diffusion facilitator (CDF) transporter familySequence: FASTACross-database IDs: LinkOrganism: Escherichia coli (strain K12)Location:
ChromosomeCompound: Iron (Fe), Zinc (Zn), Cobalt (Co), Cadmium (Cd), Nickel (Ni)Description: Iron-efflux transporter responsible for iron detoxification. Also able to transport Zn2+ in a proton-dependent manner. The CDF protein, FieF, is mainly a ferrous iron detoxifying protein but also mediated some resistance against other divalent metal cations such as Zn(II), Co(II), Cd(II), and Ni(II) in W. metallidurans or Escherichia coli.Length (amino acid):
300Reference: Grass et al. 2005; Pubmed- 15549269, Munkelt et al. 2004; Pubmed- 15547276
| Similar
resistance genes in 'BacMet Predicted database' |
fptA | BacMet ID: BAC0168Code for:
PorinFamily: General Bacterial Porin family (GBP) superfamily. TonB-dependent receptor familySequence: FASTACross-database IDs: LinkOrganism: Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)Location:
ChromosomeCompound: Iron (Fe), Cobalt (Co), Nickel (Ni), Gallium (Ga)Description: Fe(3+)-pyochelin receptor FptA; High-affinity outer membrane receptor required for the transport of Fe3+-pyochelinLength (amino acid):
720Reference: Braud et al. 2009; Pubmed- 19329644
| Similar
resistance genes in 'BacMet Predicted database' |
fpvA | BacMet ID: BAC0169Code for:
PorinFamily: General Bacterial Porin family (GBP) superfamily. TonB-dependent receptor familySequence: FASTACross-database IDs: LinkOrganism: Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)Location:
ChromosomeCompound: Manganese (Mn), Iron (Fe), Cobalt (Co), Zinc (Zn), Nickel (Ni), Copper (Cu), Cadmium (Cd), Gallium (Ga)Description: Ferripyoverdine receptor A (fpvA); Receptor for the siderophore ferripyoverdine; Located in cell outer membraneLength (amino acid):
815Reference: Hannauer et al. 2012; Pubmed- 22187978, Braud et al. 2009; Pubmed- 19207567
| Similar
resistance genes in 'BacMet Predicted database' |
kmtR | BacMet ID: BAC0201Code for:
RegulatorFamily: Contains 1 HTH arsR-type DNA-binding domainSequence: FASTACross-database IDs: LinkOrganism: Mycobacterium tuberculosisLocation:
ChromosomeCompound: Nickel (Ni), Cobalt (Co)Description: HTH-type transcriptional regulator KmtR; response to cobalt and nickel ions; Negatively auto-regulatedLength (amino acid):
130Reference: Campbell et al. 2007; Pubmed- 17726022
| Similar
resistance genes in 'BacMet Predicted database' |
mco | BacMet ID: BAC0205Code for:
EnzymeFamily: Multicopper oxidase (mco) familySequence: FASTACross-database IDs: LinkOrganism: Staphylococcus aureusLocation:
ChromosomeCompound: Copper (Cu), Cobalt (Co)Description: Multicopper oxidase Mco; Involved in copper homeostasis and oxidative stress response. Oxidizes the substrate 3,3'-dimethoxybenzidine in vitro. Also possesses low levels of phenoloxidase and ferroxidase activities. A transposon-induced mutant showed copper and cobalt sensitivity and H2O2 tolerance.Length (amino acid):
447Reference: Sitthisak et al. 2005; Pubmed- 16151171
| Similar
resistance genes in 'BacMet Predicted database' |
mgtA | BacMet ID: BAC0642Code for:
EnzymeFamily: Cation transport ATPase (P-type) familySequence: FASTACross-database IDs: LinkOrganism: Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)Location:
ChromosomeCompound: Cobalt (Co), Magnesium (Mg)Description: Mediates magnesium influx to the cytosol.Length (amino acid):
902Reference: Tao et al. 1995; Pubmed- 7751273
| Similar
resistance genes in 'BacMet Predicted database' |
mgtA | BacMet ID: BAC0087Code for:
EnzymeFamily: Cation transport ATPase (P-type) familySequence: FASTACross-database IDs: LinkOrganism: Escherichia coli (strain K12)Location:
ChromosomeCompound: Cobalt (Co), Magnesium (Mg)Description: Magnesium-transporting ATPase, P-type 1; Mediates magnesium influx to the cytosol.Length (amino acid):
898Reference: Park et al. 1976; Pubmed- 780341, Minagawa et al. 2003; Pubmed- 12813061,
| Similar
resistance genes in 'BacMet Predicted database' |
mntH/yfeP | BacMet ID: BAC0251Code for:
Membrane TransporterFamily: NRAMP familySequence: FASTACross-database IDs: LinkOrganism: Escherichia coli (strain K12)Location:
ChromosomeCompound: Manganese (Mn), Iron (Fe), Cadmium (Cd), Cobalt (Co), Zinc (Zn)Description: Divalent metal cation transporter MntH; H+-stimulated, divalent metal cation uptake system. Involved in manganese and iron uptake. Can also transport cadmium, cobalt, zinc and to a lesser extent nickel and copper. Involved in response to reactive oxygen.Length (amino acid):
412Reference: Makui et al. 2000; Pubmed- 10712688
| Similar
resistance genes in 'BacMet Predicted database' |
mrdH | BacMet ID: BAC0254Code for:
Membrane TransporterFamily: NicO familySequence: FASTACross-database IDs: LinkOrganism: Pseudomonas putida (strain KT2440)Location:
Plasmid pWW0 (Pseudomonas putida (Arthrobacter siderocapsulatus))Compound: Nickel (Ni), Cadmium (Cd), Zinc (Zn), Cobalt (Co)Description: Membrane protein transpoeter mrdHLength (amino acid):
377Reference: Haritha et al. 2009; Pubmed- 19648243
| Similar
resistance genes in 'BacMet Predicted database' |
nccA | BacMet ID: BAC0549Code for:
EffluxFamily: RND superfamily, AcrB/AcrD/AcrF familySequence: FASTACross-database IDs: LinkOrganism: Alcaligenes xylosoxidans 31ALocation:
Plasmid pTOM9Compound: Nickel (Ni), Cobalt (Co), Cadmium (Cd)Description: Nickel-cobalt-cadmium resistance protein NccA. Component of the NCC cation-efflux system (nccYXHCBAN) that confers resistance to nickel, cobalt and cadmium. May form a membrane tunnel, which allows ion transport across the membrane.Length (amino acid):
1076Reference: Schmidt et al. 1994; Pubmed- 7961470
| Similar
resistance genes in 'BacMet Predicted database' |
nccB | BacMet ID: BAC0550Code for:
EffluxFamily: RND superfamily, Membrane Fusion Protein (MFP) familySequence: FASTACross-database IDs: LinkOrganism: Alcaligenes xylosoxidans 31ALocation:
Plasmid pTOM9Compound: Nickel (Ni), Cobalt (Co), Cadmium (Cd)Description: Nickel-cobalt-cadmium resistance protein NccB. Component of the NCC cation efflux system ((nccYXHCBAN)) that confers resistance to nickel, cobalt and cadmium. Length (amino acid):
397Reference: Schmidt et al. 1994; Pubmed- 7961470
| Similar
resistance genes in 'BacMet Predicted database' |
nccC | BacMet ID: BAC0551Code for:
EffluxFamily: RND superfamily, Outer Membrane factor (OMF) familySequence: FASTACross-database IDs: LinkOrganism: Alcaligenes xylosoxidans 31ALocation:
Plasmid pTOM9Compound: Nickel (Ni), Cobalt (Co), Cadmium (Cd)Description: Nickel-cobalt-cadmium resistance protein NccC. Component of the NCC cation-efflux system (nccYXHCBAN)) that confers resistance to nickel, cobalt and cadmium.Length (amino acid):
437Reference: Schmidt et al. 1994; Pubmed- 7961470
| Similar
resistance genes in 'BacMet Predicted database' |
nccH | BacMet ID: BAC0555Code for:
RegulatorFamily: Sigma-70 factor family. ECF subfamilySequence: FASTACross-database IDs: LinkOrganism: Alcaligenes xylosoxidans 31ALocation:
Plasmid pTOM9Compound: Nickel (Ni), Cobalt (Co), Cadmium (Cd)Description: RNA polymerase sigma factor NccH. Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor regulates the genes for a membrane-located efflux system ((nccYXHCBAN) that confers resistance to nickel, cobalt and cadmium.Length (amino acid):
186Reference: Schmidt et al. 1994; Pubmed- 7961470
| Similar
resistance genes in 'BacMet Predicted database' |
nccN | BacMet ID: BAC0554Code for:
Membrane TransporterFamily: Contains 1 Phospholipid methyltransferase domainSequence: FASTACross-database IDs: LinkOrganism: Alcaligenes xylosoxidans 31ALocation:
Plasmid pTOM9Compound: Nickel (Ni), Cobalt (Co), Cadmium (Cd)Description: Nickel-cobalt-cadmium resistance protein NccN. Component of the NCC cation-efflux system (nccYXHCBAN) that confers resistance to nickel, cobalt and cadmium. Appears to be involved in metal specificity but affects only nickel resistance. May be involved in nickel transport.Length (amino acid):
213Reference: Schmidt et al. 1994; Pubmed- 7961470
| Similar
resistance genes in 'BacMet Predicted database' |
nccX | BacMet ID: BAC0553Code for:
RegulatorFamily: contains 1 heavy-metal resistance domainSequence: FASTACross-database IDs: LinkOrganism: Alcaligenes xylosoxidans 31ALocation:
Plasmid pTOM9Compound: Nickel (Ni), Cobalt (Co), Cadmium (Cd)Description: Nickel-cobalt-cadmium resistance protein NccX. Component of the Ncc cation-efflux system ((nccYXHCBAN)) that confers resistance to nickel, cobalt and cadmium. May be involved in the regulation of Ncc.Length (amino acid):
148Reference: Schmidt et al. 1994; Pubmed- 7961470
| Similar
resistance genes in 'BacMet Predicted database' |
nccY | BacMet ID: BAC0552Code for:
RegulatorFamily: UnknownSequence: FASTACross-database IDs: LinkOrganism: Alcaligenes xylosoxidans 31ALocation:
Plasmid pTOM9Compound: Nickel (Ni), Cobalt (Co), Cadmium (Cd)Description: Nickel-cobalt-cadmium resistance protein NccY. Component of the Ncc cation-efflux system that confers resistance to nickel, cobalt and cadmium. May be involved in the regulation of Ncc.Length (amino acid):
95Reference: Schmidt et al. 1994; Pubmed- 7961470
| Similar
resistance genes in 'BacMet Predicted database' |
ncrA | BacMet ID: BAC0698Code for:
EffluxFamily: MFS superfamilySequence: FASTACross-database IDs: LinkOrganism: Serratia marcescens strain C-1Location:
ChromosomeCompound: Cobalt (Co), Nickel (Ni)Description: Part of the ncrABC determinant sytem. NcrA contributes to nickel and cobalt resistance in this bacterium.Length (amino acid):
432Reference: Marrero et al. 2007; Pubmed- 17186148
| Similar
resistance genes in 'BacMet Predicted database' |
ncrA | BacMet ID: BAC0702Code for:
EffluxFamily: MFS superfamilySequence: FASTACross-database IDs: LinkOrganism: Hafnia alvei 5-5Location:
Plasmid pNRS148Compound: Cobalt (Co), Nickel (Ni)Description: Plasmid-borne ncrA protein. It encodes a membrane protein that forms an efflux with another membrane protein ncrC. Part of ncrABCY nickel resistance determinant system.Length (amino acid):
277Reference: Park et al. 2004; Pubmed- 15179604
| Similar
resistance genes in 'BacMet Predicted database' |
ncrB | BacMet ID: BAC0699Code for:
RegulatorFamily: Transcriptional repressor metal familySequence: FASTACross-database IDs: LinkOrganism: Serratia marcescens strain C-1Location:
ChromosomeCompound: Cobalt (Co), Nickel (Ni)Description: Probabale metal-sensitive repressor, involved in resistance to nickel ions. Part of ncrABCY nickel resistance determinant system.Length (amino acid):
89Reference: Marrero et al. 2007; Pubmed- 17186148
| Similar
resistance genes in 'BacMet Predicted database' |
ncrB | BacMet ID: BAC0703Code for:
RegulatorFamily: Transcriptional repressor metal familySequence: FASTACross-database IDs: LinkOrganism: Hafnia alvei 5-5Location:
Plasmid pNRS148Compound: Cobalt (Co), Nickel (Ni)Description: Plasmid-borne ncrB protein. Probabale metal-sensitive repressor, involved in resistance to nickel ions. Part of ncrABCY nickel resistance determinant system.Length (amino acid):
301Reference: Park et al. 2004; Pubmed- 15179604
| Similar
resistance genes in 'BacMet Predicted database' |
ncrC | BacMet ID: BAC0700Code for:
EffluxFamily: Nickel-cobalt transport (NicOT) familySequence: FASTACross-database IDs: LinkOrganism: Serratia marcescens strain C-1Location:
ChromosomeCompound: Cobalt (Co), Nickel (Ni)Description: Part of ncrABCY nickel resistance determinant system. It encodes a membrane protein that forms an efflux with another membrane protein ncrA.Length (amino acid):
231Reference: Marrero et al. 2007; Pubmed- 17186148
| Similar
resistance genes in 'BacMet Predicted database' |
ncrC | BacMet ID: BAC0704Code for:
EffluxFamily: Nickel-cobalt transport (NicOT) familySequence: FASTACross-database IDs: LinkOrganism: Hafnia alvei 5-5Location:
Plasmid pNRS148Compound: Cobalt (Co), Nickel (Ni)Description: Plasmid-borne ncrC protein. Part of ncrABCY nickel resistance determinant system. It encodes a membrane protein that forms an efflux with another membrane protein ncrA.Length (amino acid):
152Reference: Park et al. 2004; Pubmed- 15179604
| Similar
resistance genes in 'BacMet Predicted database' |
ncrY | BacMet ID: BAC0701Code for:
RegulatorFamily: Bacterial OB fold (BOF) protein familySequence: FASTACross-database IDs: LinkOrganism: Hafnia alvei 5-5Location:
Plasmid pNRS148Compound: Cobalt (Co), Nickel (Ni)Description: Plasmid-borne NcrY protein. Part of ncrABCY nickel resistance determinant system. Some claims it has a negative effect on nickel resistance.Length (amino acid):
63Reference: Park et al. 2004; Pubmed- 15179604
| Similar
resistance genes in 'BacMet Predicted database' |
nczA | BacMet ID: BAC0267Code for:
RegulatorFamily: RND superfamily, AcrB/AcrD/AcrF familySequence: FASTACross-database IDs: LinkOrganism: Caulobacter crescentus (strain NA1000 / CB15N)Location:
ChromosomeCompound: Nickel (Ni), Cobalt (Co), Zinc (Zn)Description: Nickel-cobalt-zinc resistance protein nczA; part of the nczCBA operon; The nczCBA operon is induced maximally by Ni2+ and Co2+, moderately by Zn2+ but not by Cd2+. NczCBA transports Ni2+ Co2+ and probably Zn2+Length (amino acid):
1057Reference: Valencia et al. 2013; Pubmed- 23578014
| Similar
resistance genes in 'BacMet Predicted database' |
nhlF | BacMet ID: BAC0268Code for:
EnzymeFamily: Nickel-cobalt transport (NicOT) familySequence: FASTACross-database IDs: LinkOrganism: Rhodococcus rhodochrousLocation:
ChromosomeCompound: Cobalt (Co)Description: Cobalt transporter nhlF. It has a significant sequence similarity to hoxN from Alcaligenes eutrophus, hupN from Bradyrhizobium japonicum, nixA from Helicobacter pylori etc. The protein has eight hydrophobic putative membrane-spanning domains.Length (amino acid):
352Reference: Komeda et al. 1997; Pubmed- 8990157
| Similar
resistance genes in 'BacMet Predicted database' |
nreB | BacMet ID: BAC0285Code for:
EnzymeFamily: MFS superfamilySequence: FASTACross-database IDs: LinkOrganism: Acromobacter xylosoxidans 31A, Synechocystis spp.Location:
Plasmid pMOL30 (Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839)),Compound: Cobalt (Co), Nickel (Ni)Description: Nickel resistance protein nreB (also known as nrsD or entS); nickel permease involved in nickel and cobalt tolerance. The histidine-rich C-terminal region of the nreB is not essential but contributes to maximal Ni(II) resistance. Length (amino acid):
416Reference: Grass et al. 2001; Pubmed- 11292799
| Similar
resistance genes in 'BacMet Predicted database' |
nrsD/nreB | BacMet ID: BAC0287Code for:
EnzymeFamily: MFS superfamilySequence: FASTACross-database IDs: LinkOrganism: Acinetobacter calcoaceticus (strain PHEA-2), Synechocystis sp. (strain PCC 6803 / Kazusa)Location:
ChromosomeCompound: Nickel (Ni), Cobalt (Co)Description: nrsD gene encodes a Ni(II) permease whose carboxy-terminal region is a metal binding domain; nickel permease involved in nickel and cobalt toleranceLength (amino acid):
445Reference: Garcia-Dominquez et al. 2000; Pubmed- 10692354
| Similar
resistance genes in 'BacMet Predicted database' |
rcnA/yohM | BacMet ID: BAC0330Code for:
EffluxFamily: NicO transporter familySequence: FASTACross-database IDs: LinkOrganism: Escherichia coli (strain K12)Location:
ChromosomeCompound: Cobalt (Co), Nickel (Ni), Iron (Fe)Description: Efflux system rcnA for nickel and cobalt; Transcriptionally repressed by RcnR. Probably also regulated by Fur. Cadmium, copper and zinc have no effect on the transcriptionLength (amino acid):
274Reference: Rodrigue et al. 2005; Pubmed- 15805538, Koch et al. 2007; Pubmed- 17120142
| Similar
resistance genes in 'BacMet Predicted database' |
rcnB/yohN | BacMet ID: BAC0331Code for:
EffluxFamily: RcnB familySequence: FASTACross-database IDs: LinkOrganism: Escherichia coli (strain K12)Location:
ChromosomeCompound: Nickel (Ni), Cobalt (Co)Description: Nickel/cobalt homeostasis protein RcnB; Act by modulating RcnA-mediated export of these ions to avoid excess efflux. Not involved in nickel import and does not bind nickel or cobalt ions directly. Repressed by RcnR. Induced by nickel and cobaltLength (amino acid):
112Reference: Bleriot et al. 2011; Pubmed- 21665978
| Similar
resistance genes in 'BacMet Predicted database' |
rcnR/yohL | BacMet ID: BAC0332Code for:
RegulatorFamily: FrmR/RcnR familySequence: FASTACross-database IDs: LinkOrganism: Escherichia coli (strain K12)Location:
ChromosomeCompound: Cobalt (Co), Nickel (Ni), Iron (Fe)Description: Repressor of rcnA, rcnR. Acts by binding specifically to the rcnA promoter in the absence of nickel and cobalt. In the presence of one of these metals, it has a weaker affinity for rcnA promoter. Can repress the rcnB expression as well.Length (amino acid):
90Reference: Koch et al. 2007; Pubmed- 17120142
| Similar
resistance genes in 'BacMet Predicted database' |
zupT/ygiE | BacMet ID: BAC0469Code for:
PorterFamily: ZIP transporter family, ZupT subfamilySequence: FASTACross-database IDs: LinkOrganism: Escherichia coli (strain K12)Location:
ChromosomeCompound: Zinc (Zn), Iron (Fe), Cobalt (Co), Nickel (Ni), Copper (Cu), Cadmium (Cd)Description: Zinc transporter ZupT; Mediates zinc uptake. May also transport other divalent cations such as copper and cadmium ions.Length (amino acid):
257Reference: Grass et al. 2005; Pubmed- 15716430
| Similar
resistance genes in 'BacMet Predicted database' |